Jessi Glaser is a sarcastic, popular and intelligent girl who is arguably the main female character in Big Mouth, and somewhat early in terms of physical and emotional development . She is a good friend of Andrew, Missy, Nick and Jay, and she has previously been involved romantically with the last two.
Jessi comes from a dysfunctional Jewish family where hostility and arguments is the norm. Her mother was unfaithful in her marriage (having had an affair with a local cantor), and her father has a severe dependency on drugs, particularly marijuana. This has caused Jessi to "act out" in a number of ways, including her on-again-off-again relationship with Jay Bilzerian and attempting to flee her old life to run away with him.
Jessi is a somewhat tall redhead with a frequently deadpan expressione. She frequently ties her hair to the side, and wears a lavender-coloured blouse on top of bright crimson leggings. Though she is more physically developed than some of her peers (particularly Missy), she is perpetually insecure of the small size of her breasts, particularly in comparison to Fatima, the romantic protagonist of The Rock Of Gibraltar.
Jessi is an intelligent girl with a dry sense of humour, although despite her negative attitude, she's very likeable and shows strong affection towards her friends (despite that she might poke fun at them from time to time). She is in recovery from depression, as well as issues surrounding her family, and attends regular sessions with a therapist.